Shaanxi Fujie Pharmaceutical Co.,Ltd

Licorice Cosmetic Ingredient

Enoxolone Anti Inflammatory

Enoxolone Anti Inflammatory

Enoxolone Anti Inflammatory
Product Name : Enoxolone anti-inflammatory
· Resource: 100% licorice roots
· Certificate: GMP
· HS Code: 2938909030
· Specification: 10KG/carton
· Molecular formula: C30H46O4
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Enoxolone Anti Inflammatory

Basic Info

· Product Name: Enoxolone anti-inflammatory

· Resource: 100% licorice roots

· Certificate: GMP 

· Shelf Life:36 moths

· TOrigin: Shaanxi , China

· HS Code: 2938909030

· Trademark: FUJIE

· Specification: 10KG/carton

· Molecular formula:C30H46O4

· Molecular weight:470.7

· CAS NO:471-53-4

· Action and use: Cosmetics industry use in inflammatory

 

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structural formula    

Solubility:Practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride.It shows polymorphism .

Specification:

Item

Specification

Assay

98.0-101.0%(dired substance)

Identification

Complies by TLC

Coloured reaction

Positive

Appearance

Fine Powder

Color

White or alomost

Melting point:

288-297℃

Rotation :

+145° - +154°

Loss on Drying

≤0.5%

Related Substance

 

Any impurity

 

≤0.7%

 

Total impurity

 

≤2.0%

 

Heavy metals

≤10ppm

 

Sulphated Ash

 

≤0.2%

 

Total Plate Count

NMT1000cfu/g

Total Yeast & Mold

NMT100cfu/g

E.Coli

Negative

Salmonella

Negative

 Storage:

 in sealed containers at cool & dry place.

Protect from light, moisture and pest infestation.

Anderso and Tillman was first noticed Enoxolone  with hydrocortisone is similar in structure, it is used for the treatment of various skin diseases, by many clinical trials to confirm the effectiveness of Enoxolone anti-inflammatory. Therefore, a series of pharmacological studies have been carried out in the medical community, and many of these derivatives have anti-inflammatory activities. Zakirov's study found that 3- amino -11- deoxyglycyrrhizic acid showed clear anti - inflammatory activity in aseptic arthritis of all kinds of animals. Toyoshima et al. prepared 11- deoxidized glycyrrhizic acid maleate and its salt, as an anti - inflammatory agent, also as an anti-ulcer and immunomodulator, oral or local treatment, all achieved good curative effect.

Enoxolone  has the anti - inflammatory effect of butadipine or hydrocortisone. Enoxolone  has inhibitory effect on the granuloma of cotton granuloma of rats and the inflammation of the subcutaneous granulomatous inflammation, which is about 1/10 of cortisone or hydrogenation. The experimental arthritis in rats induced by glycyrrhizin was inhibited, and there was a different degree of inhibitory effect on the allergic reaction of guinea pigs. Its anti-inflammatory and antiallergic reactions may be associated with inhibition of capillary permeability, antihistamine, or decreased cell response to stimulation.

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