Shaanxi Fujie Pharmaceutical Co.,Ltd

Licorice Active Pharmaceutical Ingredient

Pharmaceutical Grade 18-beta-glycyrrhetinic Acid
Pharmaceutical Grade 18-beta-glycyrrhetinic AcidProduct Name: Pharmaceutical grade 18-beta-glycyrrhetinic acid
· Resource: Radix Glycyrrhiza roots
· Certificate: China of GOOD MANUFACTURING PRACTICES
· Shelf Life:twenty-four-moths
· Transport Package: 500g*20 aluminium foil bag every Paper Drum
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Pharmaceutical grade 18-beta-glycyrrhetinic acid

Basic Info

· Product Name: Pharmaceutical grade 18-beta-glycyrrhetinic acid

· Resource: Radix Glycyrrhiza roots

· Certificate: China of GOOD MANUFACTURING PRACTICES

· Shelf Life:twenty-four-moths

· Transport Package:  500g*20 aluminium foil bag every Paper Drum

· Origin: Xian ,

· Appearance: This product is white or almost white crystalline powder.

· HS Code: 2938909030 

Content: 98.0 per cent to 101.0 per cent (dried substance).

· Trademark: FUJIE

· Molecular formula:C30H46O4

· Molecular weight:470.73

· CAS NO:471-53-4

· Action and use: peptic ulcer disease.

Grade:European Pharmacopoeia 9.0

structural formula

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Solubility:Pharmaceutical Grade 18-beta-glycyrrhetinic acid practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride.It shows polymorphism .

annual production:Shaanxi fujie pharmaceutical co.,ltd factory can product Pharmaceutical Grade 18-beta-glycyrrhetinic acid fifty dons every year.

Superiority: we are only have cGMP  in china.

Enoxolone (INNBAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties. It has some additional pharmacological properties including antiviral, antifungal, antiprotozoal, and antibacterial activities

Mechanism of action

Glycyrrhetinic acid inhibits the enzymes (15-hydroxyprostaglandin dehydrogenase and delta-13-prostaglandin) that metabolize the prostaglandins PGE-2 and PGF-2α to their respective 15-keto-13,14-dihydro metabolites which are inactive.This causes an increased level of prostaglandins in the digestive system.Prostaglandins inhibit gastric secretion but stimulate pancreatic secretion and mucous secretion in the intestines and markedly increase intestinal motility.They also cause cell proliferation in the stomach.The effect on gastric acid secretion, promotion of mucous secretion and cell proliferation shows why licorice has potential in treating peptic ulcer.

PGF-2α stimulates activity of the uterus during pregnancy and can cause abortion, therefore, licorice should not be taken during pregnancy.

The structure of glycyrrhetinic acid is similar to that of cortisone. Both molecules are flat and similar at position 3 and 11. This might be the basis for licorice's anti-inflammatory action.

3-β-D-(Monoglucuronyl)-18-β-glycyrrhetinic acid, a metabolite of glycyrrhetinic acid, inhibits the conversion of 'active' cortisol to 'inactive' cortisone in the kidneys.This occurs via inhibition of the enzyme by inhibiting the enzyme 11-β-hydroxysteroid dehydrogenase. As a result, cortisol levels are high within the collecting duct of the kidney. Cortisol has intrinsic mineralocorticoid properties (that is, it acts like aldosterone and increases sodium reabsorption) that work on ENaC channels in the collecting duct.Hypertension develops due to this mechanism of sodium retention. People often have high blood pressure with a low renin and low aldosterone blood level.The increased amounts of cortisol binds to the unprotected, unspecific mineralocorticoid receptors and induce sodium and fluid retention, hypokalaemiahigh blood pressure and inhibition of the renin-angiotensin-aldosterone system. Therefore, licorice should not be given to patients with a known history of hypertension in doses sufficient to inhibit 11-β-hydroxysteroid dehydrogenase



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