Shaanxi Fujie Pharmaceutical Co.,Ltd

Licorice Active Pharmaceutical Ingredient

18-beta-glycyrrhetinic Acid EP

18-beta-glycyrrhetinic Acid EP

Product Name: 18-beta-glycyrrhetinic acid EP
· Resource: 100% natural Radix Glycyrrhiza roots
· Certificate:GMP certification
· Shelf Life:24 months
· Transport Package: 10kg every Paper Drum
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18-beta-glycyrrhetinic acid EP

Basic Info

· Product Name: 18-beta-glycyrrhetinic acid EP

· Resource: 100% natural Radix Glycyrrhiza roots

· Certificate:GMP certification

· Shelf Life:24 months

· Transport Package:  10kg every Paper Drum

· Origin: Shaanxi , China

· Appearance: White crystalline fine powder.

· HS Code: 2938909030 

Content: 98.0 %-101.0 %(dried substance).

· Trademark: FUJIE

· Molecular formula:C30H46O4

Formula weight:470.7

CAS Number:471-53-4

Indication for use:18-beta-glycyrrhetinic acid EP can widely use for treatment peptic ulcer disease.

Grade:European Pharmacopoeia 9.0

Structural formula

18-beta-glycyrrhetinic acid EP.jpg

Solubility:18-beta-glycyrrhetinic acid EP practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride.It shows polymorphism .

annual production:our factory  can product 18-beta-glycyrrhetinic acid EP 50000KG every year

Why choose us?: we are china biggest manufacturer in china.we are only have 18-beta-glycyrrhetinic acid GMP in china.18 Beta Glycyrrhetinic Acid EP is an ester of Glycyrrhetinic Acid that is used to Soften, Sooth, and Smooth in skin care products. This product can enhance moisturizing and hydration. It is an excellent exfoliate and helps beautify and is approved for use in cosmetic and personal care products.

Product Synonyms

Enoxolone;

Glycyrrhetinic acid;

Glycyrrhetic acid;

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid;

18-beta-Glycyrrhetinic acid;

3b-Hydroxy-11-oxo-18b,20b-olean-12-en-29-oic acid;

3.beta.-Hydroxy-11-oxo-12-oleanen-30-oicacid

3-beta-hydroxy-11-oxo-olean-12-en-30-oicaci

3-beta-hydroxy-11-oxoolean-12-en-30-oicacid

3-hydroxy-11-oxo-,(3.beta.,20.beta.)-Olean-12-en-29-oicacid

3-hydroxy-11-oxo-,(3beta,20beta)-olean-12-en-29-oicaci

3-Hydroxy-11-oxo-12-oleanen-30-oicacid

biosone

Glycyrheticacid

glycyrrhetin

Olean-12-en-29-oicacid,3-hydroxy-11-oxo-,(3.beta.,20.beta.)-

18-BETA-GLYCYRRHETINIC ACID

18B-GLYCYRRHETINIC ACID

3BETA-HYDROXY-11-OXO-18BETA, 20BETA-OLEAN-12-EN-29-OIC ACID

3BETA-HYDROXY-11-OXO-18BETA-OLEAN-12-EN-30-OIC ACID

3b-hydroxy-11-oxo-18b,20b-olean-12-en-29-oic acid

3B-HYDROXY-11-OXO-18B-OLEAN-12-EN-30-OIC ACID

GLYCYRRHETINIC ACID

GLYCYRRHETIC ACID

GLYCYRRHETINIC ACID, 18B-

ENOXOLONE

ENOLOXONE

B-GLYCYRRHETINIC ACID

B-GLYCYRRNETINIC ACID

URALENIC ACID

3β-Hydroxy-11-oxoolean-12-en-30-oic acid

18-beta-Glycyrrhetinic acid, 98+%

Glycyrrhetinic

ENOXACIN GLUCONATE/18BETA-GLYCYRRHETINIC ACID

GLCYRRHETINIC ACID

CARBENOXOLONE(P)

Clycyrrhetinic Acid

18-Beta-Glycyrrheticacid,Uralenicacid

18β-Glycyrrhetic acid

Arthrodont

GM 1658

NSC 35347

Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-

Olean-12-en-30-oic acid, 3β-hydroxy-11-oxo- (8CI)

PO 12

STX 352

Subglycyrrhelinic acid

Uralenic acid (7CI)

GLYCERRHETINICACID

(3β,20b)-3-Hydroxy-11-oxo-olean-12-en-29-oic acid

18-beta-GLYCYRRHETINIC ACID hplc

18-B-GLYCYRRHETINIC ACID WITH HPLC

18-SS-GLYCYRRHETINICACID

Enoxolone, 3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid

Aloe Vera, Freeze Dried Powder

Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3b,20b)-

(20S)-3β-Hydroxy-11-oxo-5α-olean-12-en-29-oic acid

GLYCYRRHETINIC ACID, 18B-(P)

Glycyrrhetinic acid ,98%

In-vitro 18-β Glycyrrhetinic Acid testing on anti-inflammatory effect

Tumor necrosis factor alpha (TNF-α) is a cell signaling protein involved in inflammation. In this study, macrophages were pretreated with licorice root-derived compounds—glycyrrhizin, dipotassium glycyrrhizate (DPG), or 18-β glycyrrhetinic acid (18-β GA)—for 30 minutes and then treated with 100 ng/mL LPS (to induce an “inflammatory response”) for 24 hours. TNF-α concentration was then measured by ELISA. Of the three compounds, 18-β Glycyrrhetinic Acid showed the strongest dose-dependent suppression of LPS-induced TNF-α production.

 

18-beta-glycyrrhetinic acid EP extraction and refinement.

At present, 18-beta-glycyrrhetinic acid EPcan be extracted from two channels: it can be straight from licorice.After extracting 18-beta-glycyrrhetinic acid EP; Glycyrrhizinate is also extracted and 18-beta-glycyrrhetinic acid EP is extracted from it. twoAll kinds of pathways need to be lysed by glycosylated glycosides.Catalytic hydrolysis of alkali and enzyme, acetic reaction, oxidation cracking reaction. preface Acid catalytic hydrolysis was used to extract the materials.

8-beta-glycyrrhetinic acid EPmetabolic

Glycyrrhizin and most of glycyrrhizic acid derivatives were hydrolyzed to glycyrrhizic acid in the body, then absorbed into the blood through the small intestine, so the final effect was 18beta-glycyrrhizic acid. Since 8-beta-glycyrrhetinic acid EP is almost insoluble in water, the purpose of its derivatives is to introduce hydrophilic groups in the molecule to improve the bioavailability and improve the efficacy. Glycyrrhizin is absorbed into the intestine by the intestinal bacteria and then absorbed into the blood with glycyrrhizin or 3- table - glycyrrhizin. The liver is a major metabolic pathways glycyrrhizic acid salt in the body, through a series of hydroxyl, cytochrome P450 in liver cell particles involved in complete need reduced nicotinamide adenine dinucleotide phosphate as a cofactor for aerobic metabolism. In addition, a small amount of glycyrrhizate is excreted directly from the feces and is excreted in a small amount from urine.



 

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